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IsoTis OrthoBiologics manufactures bone graft substitutes and medical devices to enhance the repair and regeneration of bone in spinal and trauma surgeries. The company offers products for various orthopedic procedures, including hip, knee, shoulder and joint replacements. It provides biologically-based products for hard and soft tissue regeneration and dental applications. IsoTis OrthoBiologics offers bone matrix technology for osteoporosis, sports injuries, and automobile and heavy machinery accidents. In addition, the company provides natural, synthetic and polymer-based products for bone substitute procedures. It also offers a natural bone remodeling process. IsoTis OrthoBiologics provides an osteoconductive material to encourage bone growth. The company offers Integra Mozaik, which is engineered to mimic the composition and pore structure of natural human bone. It maintains a location in Irvine, Calif.